The outcomes of pediatric acute lymphoblastic leukemia (ALL) have improved remarkably
during the last five decades. Such improvements were made possible by the incorporation of …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some
contemporary clinical trials. However, the dose intensity of conventional chemotherapy has …

Human cancers are characterized by a number of hallmarks, including sustained
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …

Inhibition of monocarboxylate transporter 1 has been proposed as a therapeutic approach to
perturb lactate shuttling in tumor cells that lack monocarboxylate transporter 4. We examined …

Leukemia is known as a progressive malignant disease, which destroys the blood‐forming
organs and results in adverse effects on the proliferation and development of leukocytes and …

Evasion of apoptosis is a hallmark of cancer, which is frequently mediated by upregulation of
the antiapoptotic BCL-2 family proteins. In colorectal cancer (CRC), previous work has …

Simple Summary Outcome of patients with Philadelphia-chromosome positive acute
lymphoblastic leukemia (Ph+ ALL) dramatically improved during the past 20 years with the …

Deregulated cellular apoptosis is a hallmark of cancer and chemotherapy resistance. The B-
cell lymphoma 2 (BCL-2) protein family members are sentinel molecules that regulate the …

Both siRNA and miRNA can serve as powerful gene-silencing reagents but their specific
delivery to cancer cells in vivo without collateral damage to healthy cells remains …