The growing realization that biologically active polypeptides can be grouped in families, the
members of which show structural and functional relatedness, is illustrated by the four …

Receptors for peptide hormones and neurotransmitters are integral components of the
plasma membrane of cells which serve to couple the external milieu to the intracellular …

With [125I] insulin at 7× 10-10 M, 25% of the radioactivity was bound to plasma membranes
purified from rat liver. 20% of the [125I] insulin binding was inhibited by unlabeled insulin at …

X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide
adopts a mainly helical conformation, which is stabilised by hydrophobic interactions …

A determination of the spatial structure of the polypeptide hormone glucagon bound to
perdeuterated dodecylphosphocholine micelles is described. A map of distance …

Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors are now a widely used, safe and
efficacious class of antidiabetic drugs, which were developed prospectively using a rational …

Publisher Summary Studies of receptor binding generally employ highly radioactive ligand
derivatives; however, knowledge of the biological activity of the radioactive derivative is …

During the course of sperm-egg interaction in mice, zona pellucida glycoprotein ZP3 (⋍ 80
kDa) serves as both receptor for sperm (JD Bleil and PM Wassarman, 1980c, Cell 20, 873 …

Dilute aqueous solutions of glucagon were investigated by high‐resolution 1H nuclear
magnetic resonance at 360 MHz. Monomeric glucagon was found to adopt predominantly …

B ERSON AND YALOW hardly ever worked directly on receptors, but they did make many
key contributions that have led to the development of this area. It will be clear that scientists …