The proteasome degrades most cellular proteins in a controlled and tightly regulated
manner and thereby controls many processes, including cell cycle, transcription, signalling …

The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority
of proteins in the cell under normal conditions. The 26S proteasome can be divided into two …

All eukaryotes rely on selective proteolysis to control the abundance of key regulatory
proteins and maintain a healthy and properly functioning proteome. Most of this turnover is …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during
neural wiring, but the full landscape of proteomic changes remains unknown due to …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control
mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an …

Proteasome is a multi-protein organelle that participates in cellular proteostasis by
destroying damaged or short-lived proteins in an organized manner guided by the …

Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in
cells and play important roles in cancer progression. Selective degradation of gain-of …

Ovarian cancer continues to be the most lethal among gynecological malignancies and the
major cause for cancer-associated mortality among women. Limitations of current ovarian …