Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …

Leishmania occurs in several developmental forms and thus undergoes complex cell
differentiation events during its life-cycle. Those are required to allow the parasite to adapt to …

One of the first steps in understanding a protein's function is to determine its localization;
however, the methods for localizing proteins in some systems have not kept pace with the …

Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

To survive extremely different environments, intracellular parasites require highly adaptable
physiological and metabolic systems. Leishmania donovani extracellular promastigotes …

Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

Parasitic diseases cause significant global morbidity and mortality, particularly in
underdeveloped regions of the world. Malaria alone causes∼ 800 000 deaths each year …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Antimonials remain the first line drug against the protozoan parasite Leishmania but their
efficacy is threatened by resistance. We carried out a RNA expression profiling analysis …

Background Drug resistance can be complex, and several mutations responsible for it can
co-exist in a resistant cell. Transcriptional profiling is ideally suited for studying complex …