The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
pathway is a key pathway through which the host regulates immune responses by …

Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …

Different innate immune pathways converge to Stimulator of interferon genes (STING) and
trigger type I interferon responses after recognition of abnormal nucleic acids in the cells …

High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients
with immunologically “cold” tumors devoid of tumor-infiltrating lymphocytes (TILs). We found …

The signaling pathway that comprises cyclic guanosine monophosphate–adenosine
monophosphate (cGAMP or GMP-AMP) synthase (cGAS) and Stimulator of Interferon Genes …

Background Despite its potential utility in delivering direct tumor killing and in situ whole-cell
tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical …

Squamous cell carcinomas, which arise from the cells that line the mucosal surfaces of the
head and neck, represent the most common type of head and neck cancers (HNSCC) …

Purpose The activation of cGAS–STING pathway can be triggered by cytosolic double-
stranded DNA (dsDNA) in tumor and non-tumor compartments. We aim to assess the …

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor usually
hyperactivated in hepatocellular carcinoma (HCC). In addition, about 14% of HCC patients …

In situ immunization (ISI) agents are an emerging and diverse class of locally acting cancer
immunotherapeutic agents designed to promote innate immune activation in the early steps …