Type IV secretion in Gram‐negative and Gram‐positive bacteria

E Grohmann, PJ Christie, G Waksman… - Molecular …, 2018 - Wiley Online Library
Type IV secretion systems (T4SSs) are versatile multiprotein nanomachines spanning the
entire cell envelope in Gram‐negative and Gram‐positive bacteria. They play important …

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

Helicobacter pylori-induced gastric inflammation and gastric cancer

F Wang, W Meng, B Wang, L Qiao - Cancer letters, 2014 - Elsevier
Helicobacter pylori (H. pylori) infect over half of the world's population. The prevalence of H.
pylori infection and the predominant genotype of H. pylori virulence factors vary …

Helicobacter pylori in Human Stomach: The Inconsistencies in Clinical Outcomes and the Probable Causes

SM Alexander, RJ Retnakumar, D Chouhan… - Frontiers in …, 2021 - frontiersin.org
Pathogenic potentials of the gastric pathogen, Helicobacter pylori, have been proposed,
evaluated, and confirmed by many laboratories for nearly 4 decades since its serendipitous …

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

NR Salama, ML Hartung, A Müller - Nature Reviews Microbiology, 2013 - nature.com
The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes
approximately 50% of the human population, but only causes overt gastric disease in a …

Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis

M Hatakeyama - Cell host & microbe, 2014 - cell.com
Helicobacter pylori is a gastric bacterial pathogen that is etiologically linked to human gastric
cancer. The cytotoxin-associated gene A (CagA) protein of H. pylori, which is delivered into …

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

X Yong, B Tang, BS Li, R Xie, CJ Hu, G Luo… - Cell communication and …, 2015 - Springer
Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric
diseases but also with several extragastric diseases. The clinical outcomes caused by H …

Helicobacter pylori and Its Role in Gastric Cancer

VE Reyes - Microorganisms, 2023 - mdpi.com
Gastric cancer is a challenging public health concern worldwide and remains a leading
cause of cancer-related mortality. The primary risk factor implicated in gastric cancer …

Coating Nanoparticles with Gastric Epithelial Cell Membrane for Targeted Antibiotic Delivery against Helicobacter pylori Infection

P Angsantikul, S Thamphiwatana, Q Zhang… - Advanced …, 2018 - Wiley Online Library
Inspired by the natural pathogen–host interactions and adhesion, this study reports on the
development of a novel targeted nanotherapeutic for the treatment of Helicobacter pylori …