Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
Interplay between circadian clock and cancer: new frontiers for cancer treatment
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
Circadian regulator BMAL1:: CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study …
D Montaigne, X Marechal, T Modine, A Coisne… - The Lancet, 2018 - thelancet.com
Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …
Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation
Circadian disruption negatively affects physiology, posing a global health threat that
manifests in proliferative, metabolic, and immune diseases, among others. Because outputs …
manifests in proliferative, metabolic, and immune diseases, among others. Because outputs …
Systems chronotherapeutics
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
Circadian rhythms and astrocytes: the good, the bad, and the ugly
MH Hastings, M Brancaccio… - Annual review of …, 2023 - annualreviews.org
This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …
Light pollution and cancer
For many individuals in industrialized nations, the widespread adoption of electric lighting
has dramatically affected the circadian organization of physiology and behavior. Although …
has dramatically affected the circadian organization of physiology and behavior. Although …
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
AM Jetten - Nuclear receptor signaling, 2009 - journals.sagepub.com
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
Metabolic rivalry: circadian homeostasis and tumorigenesis
K Kinouchi, P Sassone-Corsi - Nature Reviews Cancer, 2020 - nature.com
Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …
Perturbations of the daily cycle have been linked to elevated risk of developing cancer as …