Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

Epigenetics refers to stable alterations in gene expression with no underlying modifications
in the genetic sequence and is best exemplified by differentiation, in which multiple cell …

The increase in recent scientific studies on cancer biomarkers has brought great new
insights into the field. Moreover, novel technological breakthroughs such as long read …

Simple Summary Apart from genetic changes, cancer is characterized by epigenetic
alterations, which indicate modifications in the DNA (such as DNA methylation) and histones …

The detection of promoter region hypermethylation and transcriptional silencing has
facilitated the identification of candidate renal cell carcinoma (RCC) tumour suppressor …

Urinary bladder cancer is the fifth most common cancer in the Western world. Increasing
evidence has shown that DNA methylation in bladder cancer is expansive and is implicated …

Purpose: Epigenetic alterations are common and can now be addressed in a parallel
fashion. We investigated the methylation in bladder cancer with respect to location in …

CONTEXT: Bladder cancer diagnosis and surveillance includes cystoscopy and cytology.
The limitation of urinary cytology is its low sensitivity for low-grade recurrences. As of now …

Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or
promoter methylation; yet, recent high-throughput genomic studies have not identified key …

Purpose: The transcription factors GATA4 and GATA5 are involved in gastrointestinal
development and are inactivated by promoter hypermethylation in colorectal cancer. Here …