Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Advantages and limitations of current microgravity platforms for space biology research

F Ferranti, M Del Bianco, C Pacelli - Applied Sciences, 2020 - mdpi.com
Human Space exploration has created new challenges and new opportunities for science.
Reaching beyond the Earth's surface has raised the issue of the importance of gravity for the …

Bioreactor technologies for enhanced organoid culture

JP Licata, KH Schwab, YE Har-El… - International Journal of …, 2023 - mdpi.com
An organoid is a 3D organization of cells that can recapitulate some of the structure and
function of native tissue. Recent work has seen organoids gain prominence as a valuable …

Space farming: horticulture systems on spacecraft and outlook to planetary space exploration

MTP Nguyen, M Knowling, NN Tran, A Burgess… - Plant Physiology and …, 2023 - Elsevier
Successful human space exploration requires more products than can be taken as payload.
There is a need, therefore, for in-space circular manufacturing. Requirements for this include …

Arabidopsis telomerase takes off by uncoupling enzyme activity from telomere length maintenance in space

BB Barcenilla, AD Meyers, C Castillo-González… - Nature …, 2023 - nature.com
Spaceflight-induced changes in astronaut telomeres have garnered significant attention in
recent years. While plants represent an essential component of future long-duration space …

3D bioprinting in microgravity: opportunities, challenges, and possible applications in space

A Van Ombergen, F Chalupa‐Gantner… - Advanced …, 2023 - Wiley Online Library
Abstract 3D bioprinting has developed tremendously in the last couple of years and enables
the fabrication of simple, as well as complex, tissue models. The international space …

Effects of altered gravity on growth and morphology in Wolffia globosa implications for bioregenerative life support systems and space-based agriculture

LE Romano, JJWA van Loon, LG Izzo, M Iovane… - Scientific reports, 2024 - nature.com
Understanding the response of plants to varied gravitational conditions is vital for
developing effective food production in space bioregenerative life support systems. This …

Glycome profiling and immunohistochemistry uncover changes in cell walls of Arabidopsis thaliana roots during spaceflight

J Nakashima, S Pattathil, U Avci, S Chin… - npj …, 2023 - nature.com
A large and diverse library of glycan-directed monoclonal antibodies (mAbs) was used to
determine if plant cell walls are modified by low-gravity conditions encountered during …

Understanding reduced gravity effects on early plant development before attempting life-support farming in the moon and mars

FJ Medina, A Manzano, A Villacampa… - Frontiers in Astronomy …, 2021 - frontiersin.org
Plants are a necessary component of any system of bioregenerative life-support for human
space exploration. For this purpose, plants must be capable of surviving and adapting to …

Advances in microgravity directed tissue engineering

Y Cui, W Liu, S Zhao, Y Zhao… - Advanced Healthcare …, 2023 - Wiley Online Library
Tissue engineering aims to generate functional biological substitutes to repair, sustain,
improve, or replace tissue function affected by disease. With the rapid development of space …