The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons,
and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output …

Protein kinase CK2 (CK2) is a ubiquitous holoenzyme involved in a wide array of
developmental processes. The involvement of CK2 in events such as neurogenesis …

Protein kinase CK2 has received a surge of attention in recent years due to the evidence of
its overexpression in a variety of solid tumors and multiple myelomas as well as its …

Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates
insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration …

G protein–coupled receptors (GPCRs) transmit exogenous signals to the nucleus, promoting
a myriad of biological responses via multiple signaling pathways in both healthy and …

Abstract DARPP-32 (dopamine-and cAMP-regulated phosphoprotein with an apparent Mr of
32,000), now also known as phosphoprotein phosphatase 1 regulatory subunit 1B …

Abstract Platelets, anucleated megakaryocyte (MK)-derived cells, play a major role in
hemostasis and arterial thrombosis. Although protein kinase casein kinase 2 (CK2) is readily …

Abstract The Okur-Chung neurodevelopmental syndrome, or OCNDS, is a newly discovered
rare neurodevelopmental disorder. It is characterized by developmental delay, intellectual …

Circadian clock genes regulate energy metabolism partly through neurotrophins in the body.
The low affinity neurotrophin receptor p75 NTR is a clock component directly regulated by …