[HTML][HTML] The role of nutrition in COVID-19 susceptibility and severity of disease: a systematic review
Background Many nutrients have powerful immunomodulatory actions with the potential to
alter susceptibility to coronavirus disease 2019 (COVID-19) infection, progression to …
alter susceptibility to coronavirus disease 2019 (COVID-19) infection, progression to …
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure
Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …
proteomes in which they play a wide variety of essential roles. A critical first step in …
New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy
Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …
High-throughput functional characterization of combinations of transcriptional activators and repressors
Despite growing knowledge of the functions of individual human transcriptional effector
domains, much less is understood about how multiple effector domains within the same …
domains, much less is understood about how multiple effector domains within the same …
Harnessing UBR5 for targeted protein degradation of key transcriptional regulators
AM Taherbhoy, DL Daniels - Trends in Pharmacological Sciences, 2023 - cell.com
Targeted protein degradation (TPD) has opened the door for drugging transcriptional
regulators, yet the number of proteins targeted and E3 ligases utilized remain limited. Here …
regulators, yet the number of proteins targeted and E3 ligases utilized remain limited. Here …
Single-cell quantitative proteomic analysis of human oocyte maturation revealed high heterogeneity in in vitro–matured oocytes
Oocyte maturation is pertinent to the success of in vitro maturation (IVM), which is used to
overcome female infertility, and produced over 5000 live births worldwide. However, the …
overcome female infertility, and produced over 5000 live births worldwide. However, the …
The in vivo interaction landscape of histones H3. 1 and H3. 3
R Siddaway, S Milos, É Coyaud, HY Yun… - Molecular & Cellular …, 2022 - ASBMB
Chromatin structure, transcription, DNA replication, and repair are regulated via locus-
specific incorporation of histone variants and posttranslational modifications that guide …
specific incorporation of histone variants and posttranslational modifications that guide …
An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA
Many transcription factors contain intrinsically disordered transcription activation domains
(TADs), which mediate interactions with coactivators to activate transcription. Historically …
(TADs), which mediate interactions with coactivators to activate transcription. Historically …
Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif
W Ru, T Koga, X Wang, Q Guo, MD Gearhart… - Journal of Biological …, 2022 - ASBMB
The Spalt-like 4 transcription factor (SALL4) plays an essential role in controlling the
pluripotent property of embryonic stem cells via binding to AT-rich regions of genomic DNA …
pluripotent property of embryonic stem cells via binding to AT-rich regions of genomic DNA …
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif
D Ghoshdastidar, M Bansal - Biophysical Journal, 2022 - cell.com
Selective gene regulation is mediated by recognition of specific DNA sequences by
transcription factors (TFs). The extremely challenging task of searching out specific cognate …
transcription factors (TFs). The extremely challenging task of searching out specific cognate …