Abstract The epithelial Na+ channel (ENaC) and the acid-sensing ion channels (ASICs) form
subfamilies within the ENaC/degenerin family of Na+ channels. ENaC mediates …

Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …

BK polyomavirus nephropathy (BKVN) and allograft rejection are two closely-associated
diseases on opposite ends of the immune scale in kidney transplant recipients. The principle …

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …

Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …

Acid‐sensing ion channels (ASICs) are a family of proton‐sensing channels that are voltage
insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by …

Abstract pH is one of the most strictly controlled parameters in mammalian physiology. An
extracellular pH of~ 7.4 is crucial for normal physiological processes, and perturbations to …

Stem cell approaches have become an attractive therapeutic option for intervertebral disc
degeneration (IVDD). Nucleus pulposus mesenchymal stem cells (NP-MSCs) participate in …

The inflammatory cytokine interleukin-6 (IL-6) is a causative agent of rheumatoid arthritis
(RA), a chronic inflammatory disease complicated with degenerative arthritic cartilage …

Introduction: Pain represents a necessary physiological function yet remains a significant
pathological process in humans across the world. The transduction of a nociceptive stimulus …