Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Building and maintaining a homeostatic relationship between a host and its colonizing
microbiota entails ongoing complex interactions between the host and the microorganisms …

While mesenchymal stem cells (MSCs)-based therapy appears to be promising, there are
concerns regarding possible side effects related to the unwanted suppression of …

Paneth cells are highly specialized epithelial cells of the small intestine, where they
coordinate many physiological functions. First identified more than a century ago on the …

The production of natural antibiotic peptides has emerged as an important mechanism of
innate immunity in plants and animals. Defensins are diverse members of a large family of …

The intestinal epithelial barrier includes columnar epithelial, Paneth, goblet,
enteroendocrine, and tuft cells as well as other cell populations, all of which contribute …

As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides
when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs …

The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …