Metastasis is the most devastating stage of cancer progression and causes the majority of
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …

Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …

Background Metastasis causes the majority of cancer-related deaths worldwide. Increasing
studies have revealed that circRNAs are associated with the carcinogenesis and metastasis …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-
selective and water permeable paracellular channels. Its abundance is under fine control by …

Multiple factors act in concert to define the fate of disseminated tumor cells (DTC) to enter
dormancy or develop overt metastases. Here, we review these factors in the context of three …

Colorectal cancer (CRC) is one of the most common malignant tumours, with multiple driving
factors and biological transitions involved in its development. Claudin‐2 (CLDN2), a well …

Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer
cell survival. We now demonstrate that Claudin-2 is functionally required for colorectal …