The Electrospray Ionization (ESI) is a soft ionization technique extensively used for
production of gas phase ions (without fragmentation) of thermally labile large …

The fragmentation pathways of protonated peptides are reviewed in the present paper
paying special attention to classification of the known fragmentation channels into a simple …

Protein identification and peptide sequencing by tandem mass spectrometry requires
knowledge of how peptides fragment in the gas phase, specifically which bonds are broken …

Proteomics can be viewed as an experimental approach to explain the information
contained in genomic sequences in terms of the structure, function, and control of biological …

Large-scale protein sequencing methods rely on enzymatic digestion of complex protein
mixtures to generate a collection of peptides for mass spectrometric analysis. Here we …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

The basic principles underlying the electrospray process are reviewed without recourse to
detailed discussion of mechanisms. The essential features of the practical implementation of …

1.1. General Considerations Structural intricacies of carbohydrate molecules and their
propensity to form varied linkages, substitutions, and branching patterns have fascinated …

How to design, execute, and interpret experiments for protein sequencing using mass
spectrometry The rapid expansion of searchable protein and DNA databases in recent years …

Mass spectrometry has become the method of choice for the qualitative and quantitative
characterization of protein mixtures isolated from all kinds of living organisms. The raw data …