Despite maximal surgical and medical therapy, the treatment of glioblastoma remains a
seriously vexing problem, with median survival well under 2 years and few long-term …

In recent years, the role of neutrophils in cancer biology has been a matter of increasing
interest. Many patients with advanced cancer show high levels of neutrophilia, tumor …

Glioblastomas are highly infiltrated by diverse immune cells, including microglia,
macrophages, and myeloid-derived suppressor cells (MDSCs). Understanding the …

Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

The promise of dendritic cell (DC)–based immunotherapy has been established by two
decades of translational research. Of the four malignancies most targeted with clinical DC …

The oncolytic features of several naturally oncolytic viruses have been shown on
Glioblastoma Multiforme cell lines and in xenotransplant models. However, orthotopic …

Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with
extremely low survival rates due to late diagnosis and resistance to standard therapies. A …

Highlights•Galectins engage a number of glycosylated immune checkpoint
receptors.•Galectins alter T-cell and NK-cell activation, signaling and survival.•Galectins …

Unlike traditional cancer therapies, such as surgery, radiation and chemotherapy that are
typically non-specific, cancer immunotherapy harnesses the high specificity of a patient's …