Especially in tropical and developing countries, the clinically relevant protozoa
Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (sleeping sickness) and …

The execution of the apoptotic death program in metazoans is characterized by a sequence
of morphological and biochemical changes that include cell shrinkage, presentation of …

During its life cycle, Leishmania undergoes extreme environmental changes, alternating
between insect vectors and vertebrate hosts. Elevated temperature and decreased pH …

Apoptosis is a normal component of the development and health of multicellular organisms.
However, apoptosis is now considered a prerogative of unicellular organisms, including the …

Programmed cell death in protists does not seem to make sense at first sight. However,
apoptotic markers in unicellular organisms have been observed in all but one of the six/eight …

ABSTRACT A series of new selenocyanates and diselenides bearing interesting bioactive
scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was …

Leishmaniasis is one of the leading globally neglected diseases, affecting millions of people
worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic …

Objectives To evaluate the in vitro leishmanicidal activity of imidazole-based (1–4) and
pyrazole-based (5–6) benzo [g] phthalazine derivatives against Leishmania infantum and …

We report new organoselenium compounds bearing the sulfonamide moiety as effective
inhibitors of the β-isoform of Carbonic Anhydrase from the unicellular parasitic protozoan L …

We report for the first time a novel series of tellurides bearing sulfonamide as selective and
potent inhibitors of the β-class carbonic anhydrase (CA; EC 4.2. 1.1) enzyme expressed in …