Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss
MA Lewis, J Schulte, L Matthews, KI Vaden Jr… - PLoS …, 2023 - journals.plos.org
Adult-onset progressive hearing loss is a common, complex disease with a strong genetic
component. Although to date over 150 genes have been identified as contributing to human …
component. Although to date over 150 genes have been identified as contributing to human …
[HTML][HTML] Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction
L Qian, H Xu, R Yuan, W Yun, Y Ma - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Formononetin, an isoflavone compound, has been extensively researched due to its various
biological activities, including a potent protective effect on the cardiovascular system …
biological activities, including a potent protective effect on the cardiovascular system …
Morphine induces HADHA succinylation, while HADHA desuccinylation alleviates morphine tolerance by influencing autophagy
Y Huang, S Lu, Y Chen, Y Feng, W Lu - Naunyn-Schmiedeberg's Archives …, 2024 - Springer
Morphine tolerance is an important factor in unsatisfactory analgesia. HADHA is a crucial
enzyme in fatty acid β-oxidation. In this study, we investigated the potential significance of …
enzyme in fatty acid β-oxidation. In this study, we investigated the potential significance of …
Transcriptomic analysis reveals the lipid metabolism-related gene regulatory characteristics and potential therapeutic agents for myocardial ischemia-reperfusion …
J Wu, H Cai, X Hu, W Wu - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Background Impaired energy balance caused by lipid metabolism dysregulation is an
essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to …
essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to …
Hadh deficiency induced oligoasthenoteratozoospermia through the TNF‐α/Bcl‐2 pathway in male mice
H Zhu, H Wang, Y Cheng, D Liu, A Zhang… - The FASEB …, 2022 - Wiley Online Library
The process of spermatogenesis is a complex and delicate process that is still not fully
understood. In this study, we examined the role of fatty acid oxidase 3‐hydroxy acyl CoA …
understood. In this study, we examined the role of fatty acid oxidase 3‐hydroxy acyl CoA …
A novel isoform of hydroxyacyl-CoA dehydrogenase inhibits cell proliferation
G Xia, Y Gao, C Wu, H Pan, J Hou, J Su, S Wei… - Biochemical and …, 2022 - Elsevier
Hydroxyacyl-CoA dehydrogenase (HADH) catalyzes the third reaction of mitochondrial β-
oxidation cascade, while the regulation of its expression and function remains to be …
oxidation cascade, while the regulation of its expression and function remains to be …