Tumor is a representative of cell immortalization, while senescence irreversibly arrests cell
proliferation. Although tumorigenesis and senescence seem contrary to each other, they …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

Chronic pancreatitis is characterized by chronic inflammation and fibrosis, processes
heightened by activated pancreatic stellate cells (PSCs). Recent publications have …

Acute pancreatitis is a common acute inflammatory abdominal disease. When acute
pancreatitis progresses to severe acute pancreatitis (SAP), it can lead to systemic …

In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs)
emerge as central figures. These cells, initially in a dormant state characterized by the …

Background Acute pancreatitis (AP) is a frequent cause for hospitalization. However,
molecular determinants that modulate severity of experimental pancreatitis are only partially …

Introduction: Zinc oxide nanoparticles (ZnO-NPs) are one of metal nanoparticles that have
broadly utilized in numerous fields. Nowadays, they are increasingly utilized in food as a …

Significance Through specific tracking and ablation of PSCs, we discovered that they give
rise to a numerically small subtype of CAFs that plays a significant role in the PDAC TME …