On the specificity of protein–protein interactions in the context of disorder
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …
interactomes, the question about their specificity—or more so on their multispecificity—arise …
Unconventional recognition of peptides by T cells and the implications for autoimmunity
JF Mohan, ER Unanue - Nature Reviews Immunology, 2012 - nature.com
The interaction of antigen-presenting cells with free peptides or a denatured protein can give
rise to peptide–MHC class II complexes that are distinct from those generated after the …
rise to peptide–MHC class II complexes that are distinct from those generated after the …
Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes
Highly charged intrinsically disordered proteins can form complexes with very high affinity in
which both binding partners fully retain their disorder and dynamics, exemplified by the …
which both binding partners fully retain their disorder and dynamics, exemplified by the …
CD4+ T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy
AK De la Herran-Arita, BR Kornum, J Mahlios… - Science translational …, 2013 - science.org
Narcolepsy, a disorder strongly associated with human leukocyte antigen (HLA)–DQA1* 01:
02/DQB1* 06: 02 (DQ0602), is characterized by excessive daytime sleepiness, cataplexy …
02/DQB1* 06: 02 (DQ0602), is characterized by excessive daytime sleepiness, cataplexy …
Binding interactions between peptides and proteins of the class II major histocompatibility complex
BJ McFarland, C Beeson - Medicinal research reviews, 2002 - Wiley Online Library
The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II α-chain
E Stratikos, DC Wiley, LJ Stern - The Journal of Immunology, 2004 - journals.aai.org
The class II MHC homolog HLA-DM catalyzes exchange of peptides bound to class II MHC
proteins, and is an important component of the Ag presentation machinery. The mechanism …
proteins, and is an important component of the Ag presentation machinery. The mechanism …
Targeted cd1d molecules
B Robert, A Donda, V Cesson, JP Mach… - US Patent …, 2017 - Google Patents
US9809654B2 - Targeted CD1d molecules - Google Patents US9809654B2 - Targeted CD1d
molecules - Google Patents Targeted CD1d molecules Download PDF Info Publication …
molecules - Google Patents Targeted CD1d molecules Download PDF Info Publication …
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding
GJ Carven, S Chitta, I Hilgert, MM Rushe… - Journal of Biological …, 2004 - ASBMB
Class II major histocompatibility complex (MHC) proteins bind peptides and present them at
the cell surface for interaction with CD4+ T cells as part of the system by which the immune …
the cell surface for interaction with CD4+ T cells as part of the system by which the immune …
Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping
GJ Carven, LJ Stern - Biochemistry, 2005 - ACS Publications
Peptide binding induces conformational changes in class II MHC proteins that have been
characterized using a variety of hydrodynamic and spectroscopic approaches, but these …
characterized using a variety of hydrodynamic and spectroscopic approaches, but these …
Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms
K Tan-No, G Cebers, T Yakovleva, BH Goh… - Experimental cell …, 2001 - Elsevier
Dynorphin A, a prodynorphin-derived peptide, is able to induce neurological dysfunction
and neuronal death. To study dynorphin cytotoxicity in vitro, prodynorphin-derived peptides …
and neuronal death. To study dynorphin cytotoxicity in vitro, prodynorphin-derived peptides …