The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear
genetic component. While most SLE patients carry rare gene variants in lupus risk genes …

Aims The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth
factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to …

T and B cells have been implicated in hypertension, but the mechanisms by which they
produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 …

Chronic infusion of angiotensin-II in atheroprone (ApoE−/−) mice provides a reproducible
model of dissection in the suprarenal abdominal aorta, often with a false lumen and …

Stanford type A aortic dissection (TA-AD) is a life-threatening disease. Most cases of aortic
dissection (AD) are sporadic rather than inherited. Unlike that of inherited AD, the …

Aortic dissection is a devastating cardiovascular disease with a high lethality. Histone
variants maintain the genomic integrity and play important roles in development and …

Human SH2B3 is involved in growth factor and inflammation signaling. A SH2B3 missense
variant (rs3184504) is associated with cardiovascular diseases plus breast, colorectal, and …

Genome-wide association studies and candidate gene studies have identified several
genetic variants that might play a role in achieving longevity. This study investigates …