Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

Piezo1 and Piezo2 are recently discovered mechanosensory ion channels. Piezo channels
transduce mechanical stimulation into cellular signaling in a variety of tissues and organ …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

The classic view of the red blood cell (RBC) presents a biologically inert cell that upon
maturation has limited capacity to alter its physical properties. This view developed largely …

Mature circulating red blood cells (RBCs) are classically viewed as passive participants in
circulatory function, given erythroblasts eject their organelles during maturation …

Hereditary xerocytosis is a dominantly inherited red cell membrane disorder caused in most
cases by gain-of-function mutations in PIEZO1, encoding a mechanosensitive ion channel …

The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes
severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are …

The discovery of PIEZO proteins has enabled better understanding of how cells respond to
mechanical force. 1-3 PIEZOs assemble to form ion channels that link force to cell behavior …

This review concerns a series of dominantly inherited haemolytic anaemias in which the
membrane of the erythrocyte 'leaks' the univalent cations, compromising the osmotic stability …

Phosphatidylserine (PS) exposure is increased in red cells from sickle cell anaemia (SCA)
patients. Externalised PS is prothrombotic and attractive to phagocytes and activated …