The mycobacterial cell envelope—a moving target

CL Dulberger, EJ Rubin, CC Boutte - Nature Reviews Microbiology, 2020 - nature.com
Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

The bacterial cell wall: from lipid II flipping to polymerization

S Kumar, A Mollo, D Kahne, N Ruiz - Chemical reviews, 2022 - ACS Publications
The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

A García-Heredia, AA Pohane, ES Melzer, CR Carr… - Elife, 2018 - elifesciences.org
Rod-shaped mycobacteria expand from their poles, yet d-amino acid probes label cell wall
peptidoglycan in this genus at both the poles and sidewall. We sought to clarify the …

A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

T Kado, Z Akbary, D Motooka, IL Sparks, ES Melzer… - Elife, 2023 - elifesciences.org
Lateral partitioning of proteins and lipids shapes membrane function. In model membranes,
partitioning can be influenced both by bilayer-intrinsic factors like molecular composition …

Bacterial lipid biophysics and membrane organization

LMY Mitchison-Field, BJ Belin - Current Opinion in Microbiology, 2023 - Elsevier
The formation of lateral microdomains is emerging as a central organizing principle in
bacterial membranes. These microdomains are targets of antibiotic development and have …

Membrane-partitioned cell wall synthesis in mycobacteria

A García-Heredia, T Kado, CE Sein, J Puffal… - Elife, 2021 - elifesciences.org
Many antibiotics target the assembly of cell wall peptidoglycan, an essential,
heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall …

Cell walls and membranes of Actinobacteria

KC Rahlwes, IL Sparks, YS Morita - Bacterial Cell Walls and Membranes, 2019 - Springer
Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …

Supramolecular organisation and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane

CM Brown, RA Corey, Y Gao, YK Choi, M Gilleron… - Biophysical …, 2023 - cell.com
661-Pos Supramolecular organisation and dynamics of mannosylated phosphatidylinositol
lipids in the mycobacterial plasma membrane Chelsea M. Brown1, Robin A. Corey2, Ya …

Amidation of glutamate residues in mycobacterial peptidoglycan is essential for cell wall cross-linking

MT Shaku, KL Ocius, AJ Apostolos, MM Pires… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Mycobacteria assemble a complex cell wall with cross-linked peptidoglycan
(PG) which plays an essential role in maintenance of cell wall integrity and tolerance to …