Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Functions and inhibition of galectin-7, an emerging target in cellular pathophysiology

NV Sewgobind, S Albers, RJ Pieters - Biomolecules, 2021 - mdpi.com
Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-
galactosides. It has been described to be involved in apoptosis, proliferation and …

Galectin-8, cytokines, and the storm

Y Zick - Biochemical Society Transactions, 2022 - portlandpress.com
Galectin-8 (Gal-8) belongs to a family of animal lectins that modulate cell adhesion, cell
proliferation, apoptosis, and immune responses. Recent studies have shown that …

Galectins as emerging glyco-checkpoints and therapeutic targets in glioblastoma

GA Videla-Richardson, O Morris-Hanon… - International Journal of …, 2021 - mdpi.com
Despite recent advances in diagnosis and treatment, glioblastoma (GBM) represents the
most common and aggressive brain tumor in the adult population, urging identification of …

Ferrocene-and ruthenium arene-containing glycomimetics as selective inhibitors of human galectin-1 and-3

V Hamala, M Kurfiřt, LČ Šťastná, H Hujerová… - Inorganic Chemistry …, 2024 - pubs.rsc.org
Galectins are a family of β-galactoside-binding proteins with an evolutionarily conserved
carbohydrate recognition domain. Their dysregulation has been implicated in physiological …

Breaking barriers: How modified citrus pectin inhibits galectin-8

M Shuai, Y Li, F Guan, G Fu, C Sun, Q Ren, L Wang… - Food & Function, 2024 - pubs.rsc.org
Inhibition of galectin-3-mediated interactions by modified citrus pectin (MCP) could affect
several rate-limiting steps in cancer metastasis, but the ability of MCP to antagonize galectin …

Breast cancer glycan biomarkers: their link to tumour cell metabolism and their perspectives in clinical practice

T Bertok, V Pinkova Gajdosova… - Expert review of …, 2021 - Taylor & Francis
ABSTRACT Introduction Breast cancer (BCa) is the most common cancer type diagnosed in
women and 5th most common cause of deaths among all cancer deaths despite the fact that …

[HTML][HTML] Non-Carbohydrate Galectin-1 Inhibitors as Promising Anticancer Agents: Design Strategies, Structure Activity Relationship and Mechanistic Insights

SG Nerella - European Journal of Medicinal Chemistry Reports, 2024 - Elsevier
Galectin-1 (gal-1) emerges as a potential biomarker for cancer diagnosis, prognosis, and
therapy. Its pivotal involvement spans various stages of tumor progression, including tumor …

Lectin Receptors in Primary and Metastatic Cancer Cells

Y Herasymenko, K Herasymenko… - Asian Pacific Journal …, 2024 - journal.waocp.org
Purpose: The purpose of this study was to detect the distribution of different lectin receptors
in primary cancer cells as well as in the case of metastasis, as these biomolecules can …

[HTML][HTML] Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue

S Liu, E Takemasa, Y Suzuki, A Javkhlant… - Journal of …, 2022 - Elsevier
Purpose Aiming at complete excision of cholesteatoma during trympanomastoidectomy and
therefore reducing the risk of recurrence, intraoperative imaging techniques are required to …