Ubiquitination regulates a myriad of eukaryotic signaling cascades by modifying substrate
proteins, thereby determining their functions and fates. In this perspective, we discuss …

The modification of proteins and other biomolecules with the small protein ubiquitin has
enthralled scientists from many disciplines for decades, creating a broad research field …

DNA double-strand breaks (DSBs) elicit an elaborate response to signal damage and trigger
repair via two major pathways: nonhomologous end-joining (NHEJ), which functions …

Progress in biology has generated numerous lists of genes that share some property. But
advancing from these lists of genes to understanding their roles is slow and unsystematic …

Ubiquitination and ADP-ribosylation are two types of post-translational modification (PTM)
involved in regulating various cellular activities. In a striking example of direct interplay …