Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …

Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Quantum chemical density functional theory (DFT) calculations were performed to examine
features of metal-doped graphene (MG) models for adsorbing the popular ibuprofen (IBU) …

A new set of ibuprofen-quinoline conjugates comprising quinolinyl heterocycle and
ibuprofen moieties linked by an alkyl chain were synthesized in good yields utilizing an …

Emerging evidence points to the intertwining framework of inflammation and oxidative stress
in various ailments. We speculate on the potential impact of the magic shotgun approach in …

In an attempt to obtain new candidates with potential anti-inflammatory activity, two series of
1, 3, 4-oxadiazole based derivatives (8a–g) and 1, 2, 4-triazole based derivatives (10a, b …

Three series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were
synthesized, characterized by several spectroscopic techniques, and investigated as …

We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p)
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …

A new series of thieno [2, 3-d] pyrimidine derivatives 4, 5, 6a-o, and 11 was designed and
synthesized starting from cyclohexanone under Gewald condition with the aim to develop …

Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …