Tumor hypoxia is a common feature in most solid tumors and is associated with
overexpression of the hypoxia response pathway. Overexpression of the hypoxia‐inducible …

Transcription factors are central regulators of gene expression and critically steer
development, differentiation and death. Except for ligand-activated nuclear receptors, direct …

HSP90 is a member of the family of heat shock proteins responsible for folding proteins into
mature conformations and thus maintaining their biological function in cells. Since it is …

Ocular diseases featuring pathologic neovascularization are the leading cause of blindness,
and anti-VEGF agents have been conventionally used to treat these diseases. Recently …

Despite the development of advanced therapeutic regimens such as molecular targeted
therapy and immunotherapy, the 5-year survival of patients with lung cancer is still less than …

Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and
leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in …

A series of O-substituted analogs of the C-ring-truncated scaffold of deguelin designed as
heat shock protein 90 (HSP90) C-terminal inhibitors were investigated as novel antitumor …

Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer
metastasis treatment, 68 new aryl carboxamide compounds were synthesized and …

A series of O-substituted analogues of the B, C-ring truncated scaffold of deguelin were
designed as C-terminal inhibitors of heat shock protein 90 (HSP90) and investigated as …