NAFLD and liver transplantation: current burden and expected challenges

R Pais, AS Barritt 4th, Y Calmus, O Scatton, T Runge… - Journal of …, 2016 - Elsevier
Because of global epidemics of obesity and type 2 diabetes, the prevalence of non-alcoholic
fatty liver disease (NAFLD) is increasing both in Europe and the United States, becoming …

Expert panel review to compare FDA and EMA guidance on drug development and endpoints in nonalcoholic steatohepatitis

R Loomba, V Ratziu, SA Harrison… - …, 2022 - gastrojournal.org
Nonalcoholic steatohepatitis (NASH) has become a focus for drug development owing to its
increasing prevalence and health care burden. The global prevalence of NASH is estimated …

[HTML][HTML] Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria: a meta-analysis of 18,421 patients

JH Koh, DJH Tan, Y Ong, WH Lim, CH Ng… - … surgery and nutrition, 2022 - ncbi.nlm.nih.gov
Background Outcomes after liver resection (LR) and liver transplantation (LT) for
hepatocellular carcinoma (HCC) are heterogenous and may vary by region, over time …

[PDF][PDF] Projected increase in obesity and non‐alcoholic‐steatohepatitis–related liver transplantation waitlist additions in the United States

ND Parikh, WJ Marrero, J Wang, J Steuer… - …, 2019 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) cirrhosis is the fastest growing indication for liver
transplantation (LT) in the United States. We aimed to determine the temporal trend behind …

Making every liver count: increased transplant yield of donor livers through normothermic machine perfusion

M MacConmara, SI Hanish, CS Hwang… - Annals of …, 2020 - journals.lww.com
Objective: Normothermic machine perfusion (NMP) enables optimized ex-vivo preservation
of a donor liver in a normal physiologic state. The impact of this emerging technology on …

Improving national results in liver transplantation using grafts from donation after cardiac death donors

KP Croome, DD Lee, AP Keaveny, CB Taner - Transplantation, 2016 - journals.lww.com
Background Published reports describing the national experience with liver grafts from
donation after cardiac death (DCD) donors have resulted in reservations with their …

[PDF][PDF] Comparison of longterm outcomes and quality of life in recipients of donation after cardiac death liver grafts with a propensity‐matched cohort

KP Croome, DD Lee, DK Perry, JM Burns… - Liver …, 2017 - Wiley Online Library
The use of liver grafts from donation after cardiac death (DCD) has been limited due to the
increased rate of graft failure, mostly related to ischemic cholangiopathy (IC). It is our …

Ex vivo machine perfusion: current applications and future directions in liver transplantation

J Michelotto, JMGV Gassner, S Moosburner… - … archives of surgery, 2021 - Springer
Background Liver transplantation is the only curative treatment option for end-stage liver
disease; however, its use remains limited due to a shortage of suitable organs. In recent …

Successful donation after cardiac death liver transplants with prolonged warm ischemia time using normothermic regional perfusion

R De Carlis, S Di Sandro, A Lauterio, F Ferla… - Liver …, 2017 - journals.lww.com
The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited
by the incidence of primary nonfunction (PNF) and ischemia‐related complications. Even …

Hepatocellular carcinoma: early-stage management challenges

DJ Erstad, KK Tanabe - Journal of Hepatocellular Carcinoma, 2017 - Taylor & Francis
Hepatocellular carcinoma (HCC) is a major cause of cancer death and is increasing in
incidence. This review focuses on HCC surveillance and treatment of early-stage disease …