Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …

The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase
(h DHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from …

Simple Summary In this study, we investigated and boosted the pro-apoptotic and pro-
differentiating activity of MEDS433 in acute myeloid leukemia (AML). MEDS433 is an …

In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with
acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting …

We report a series of glutamate and aspartate analogues designed using the hydroxy-1, 2, 3-
triazole moiety as a bioisostere for the distal carboxylic acid. Compound 6b showed …

Hydroxyazoles are acidic systems that are considered isosteres of the carboxylic acid group;
because of their efficacy in exploring chemical space, they are considered an efficient …

Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …

During the optimization process that leads to drug candidates, bioisosterism is often used to
achieve improved potency/selectivity, optimal ADME-T profiles as well as reach intellectual …

Dihydroorotate dehydrogenase (DHODH), an enzyme that plays a critical role in the de novo
pyrimidine biosynthesis, has been recognized as a promising target for the treatment of …

Dihydroorotate dehydrogenase (DHODH), an enzyme that plays a critical role in the de-novo
pyrimidine biosynthesis, has been recognized as a promising target for the treatment of …