Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are a 48-member
superfamily of membrane proteins that actively transport a variety of biological substrates …

Summary Although 5%–10% weight loss is routinely recommended for people with obesity,
the precise effects of 5% and further weight loss on metabolic health are unclear. We …

Transcriptome-wide association studies using predicted expression have identified
thousands of genes whose locally regulated expression is associated with complex traits …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

The systemic decline in autophagic activity with age impairs homeostasis in several tissues,
leading to age-related diseases. A mechanistic understanding of adipocyte dysfunction with …

Until date, several machine learning approaches have been proposed for the dynamic
modeling of temporal omics data. Although they have yielded impressive results in terms of …

Cholesterol efflux is the initial step in the reverse cholesterol transport pathway by which
excess cholesterol in peripheral cells is exported and subsequently packaged into high …

High-density lipoproteins (HDLs) exert a series of potentially beneficial effects on many cell
types including anti-atherogenic actions on the endothelium and macrophage foam cells …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …