This review examines the diagnostic application of saliva for systemic diseases. As a
diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected …

Cystic fibrosis is the most common potentially lethal autosomal recessive disease of
Caucasians, affecting 1 in 2500 newborns. Since the recent identification of the gene that is …

Two types of P-glycoprotein have been found in mammals: the drug-transporting P-
glycoproteins and a second type, unable to transport hydrophobic anticancer drugs. The …

Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-
dependent chloride ion channel known as the cystic fibrosis transmembrane conductance …

The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Deletion of the phenylalanine at position 508 of the cystic fibrosis transmembrane
conductance regulator (CFTR) is the most prevalent mutation in cystic fibrosis (CF). This …

E-Cadherin plays critical roles in many aspects of cell adhesion, epithelial development, and
the establishment and maintenance of epithelial polarity. The fate of E-cadherin once it is …

Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel,
is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed …

The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane
upon vasopressin stimulation. Phosphorylation of serine 256 of AQP2 by cAMP-dependent …

Loss-of-function mutations of the ClC-5 chloride channel lead to Dent's disease, a syndrome
characterized by low molecular weight proteinuria, hypercalciuria, and kidney stones. We …