After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF)
that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by …

Embryonic development of the vertebrate eye begins with the formation of an optic vesicle
which folds inwards to form a double-layered optic cup with a fissure on the ventral surface …

Purpose: Mowat–Wilson syndrome (MWS) is a genetic disease characterized by distinctive
facial features, moderate to severe intellectual disability, and congenital malformations …

Mowat-Wilson syndrome (MWS) is characterized by distinctive facial features (widely spaced
eyes, broad eyebrows with a medial flare, low-hanging columella, prominent or pointed chin …

Background Congenital microphthalmia and coloboma are severe developmental defects
that are frequently associated with additional systemic anomalies and display a high level of …

Background Hirschsprung's disease (HSCR) is cited as a classical component in the
constellation of features found in children with Mowat–Wilson syndrome (MWS), which is …

Mowat–Wilson syndrome (MWS) is a rare genetic neurodevelopmental congenital disorder
associated with various defects of the zinc finger E-box binding homeobox 2 (ZEB2) gene …

Heart defects caused by loss‐of‐function mutations in CHD7 are a frequent cause of
morbidity and mortality in CHARGE syndrome. Here we review the clinical and molecular …

Mowat-Wilson syndrome is a rare genetic condition characterized by intellectual disability,
structural anomalies, and dysmorphic features. It is caused by haploinsufficiency of the ZEB2 …

Epigenetic events including chromatin remodeling and histone modifications have recently
emerged as important contributors to a variety of neurodevelopmental disorders. This review …