Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

Therapeutic effects and safe uses of plant-derived polyphenolic compounds in cardiovascular diseases: a review

BS Alotaibi, M Ijaz, M Buabeid, ZJ Kharaba… - Drug design …, 2021 - Taylor & Francis
Polyphenols have long been recognized as health-promoting entities, including beneficial
effects on cardiovascular disease, but their reputation has been boosted recently following a …

Quercetin inhibits the production of IL-1β-induced inflammatory cytokines and chemokines in ARPE-19 cells via the MAPK and NF-κB signaling pathways

SC Cheng, WC Huang, JH S. Pang, YH Wu… - International journal of …, 2019 - mdpi.com
Quercetin, a bioflavonoid derived from vegetables and fruits, exerts anti-inflammatory effects
in various diseases. Our previous study revealed that quercetin could suppress the …

[HTML][HTML] An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches

M Talebi, M Talebi, T Farkhondeh… - Biomedicine & …, 2021 - Elsevier
Neurological diseases are responsible for a large number of morbidities and mortalities in
the world. Flavonoids are phytochemicals that possess various health-promoting impacts …

Treatment of atherosclerosis by traditional Chinese medicine: questions and quandaries

C Wang, M Niimi, T Watanabe, Y Wang, J Liang, J Fan - Atherosclerosis, 2018 - Elsevier
Atherosclerosis and its complications, such as myocardial infarction and stroke, are the
major causes of morbidity and mortality, and development of effective therapies for both …

Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis

SE Owumi, DO Lewu, UO Arunsi… - Human & experimental …, 2021 - journals.sagepub.com
Doxorubicin is an effective anti-neoplastic agent; the reported toxicities of DOX limit its use.
Luteolin is a polyphenolic phytochemical that exhibits beneficial biological effects via …

Flavones: Six selected flavones and their related signaling pathways that induce apoptosis in cancer

SH Jeong, HH Kim, SE Ha, MY Park… - International Journal of …, 2022 - mdpi.com
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and
takes many lives. Apoptosis is a programmed cell death mechanism and if it does not …

Phenolic compounds exerting lipid-regulatory, anti-inflammatory and epigenetic effects as complementary treatments in cardiovascular diseases

L Toma, GM Sanda, LS Niculescu, M Deleanu… - Biomolecules, 2020 - mdpi.com
Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which
continue to be responsible for up to 70% of death worldwide. Despite the ongoing …

Flavonoids: Important biocompounds in food

S Ruiz-Cruz, S Chaparro-Hernández… - … : from biosynthesis to …, 2017 - books.google.com
Flavonoids are secondary metabolites in plants that show some desirable characteristics.
These compounds can be grouped in different classes on the basis of their basic structure. It …

Luteolin modulates SERCA2a via Sp1 upregulation to attenuate myocardial ischemia/reperfusion injury in mice

Y Hu, C Zhang, H Zhu, S Wang, Y Zhou, J Zhao… - Scientific Reports, 2020 - nature.com
The sarco/endoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) is responsible for calcium
transport during excitation–contraction coupling and is essential for maintaining myocardial …