The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors that
are members of the receptor tyrosine kinase family. Both DDRs bind a number of different …

Extracellular matrix (ECM) macromolecules together with a multitude of different molecules
residing in the extracellular space play a vital role in the regulation of cellular phenotype and …

We have developed a deep generative model, generative tensorial reinforcement learning
(GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility …

Dysregulation of the discoidin domain receptor (DDR1), a collagen-activated receptor
tyrosine kinase, has been linked to several human cancer diseases including non-small cell …

Discoidin domain receptor (DDR) is a collagen-activated receptor tyrosine kinase that plays
critical roles in regulating essential cellular processes such as morphogenesis …

Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of
inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease …

Cell responses to the extracellular matrix depend on specific signaling events. These are
important from early development, through differentiation and tissue homeostasis, immune …

We present a new strategy for systematic identification of phosphotyrosine (pTyr) by affinity
purification mass spectrometry (AP-MS) using a Src homology 2 (SH2)-domain-derived pTyr …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Discoidin domain receptors, DDR1 and DDR2, lie at the intersection of two large receptor
families, namely the extracellular matrix and tyrosine kinase receptors. As such, DDRs are …