Immune checkpoint inhibitors for vaccine improvements: current status and new approaches
In recent years, the use of immune checkpoint inhibitors (ICIs) in combination with approved
or experimental vaccines has proven to be a promising approach to improve vaccine …
or experimental vaccines has proven to be a promising approach to improve vaccine …
Progress in the use of antisense oligonucleotides for vaccine improvement
Antisense oligonucleotides (ASOs) are synthetically prepared short single-stranded
deoxynucleotide sequences that have been validated as therapeutic agents and as a …
deoxynucleotide sequences that have been validated as therapeutic agents and as a …
Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza …
The excessive activation of interferon regulatory factor 7 (IRF 7) promotes the development
of acute lung injury (ALI) caused by influenza A virus (IAV). However, the deficiency of IRF 7 …
of acute lung injury (ALI) caused by influenza A virus (IAV). However, the deficiency of IRF 7 …
Regulatory T cells and vaccine effectiveness in older adults. Challenges and prospects
Since the discovery of lymphocytes with immunosuppressive activity, increasing interest has
arisen in their possible influence on the immune response induced by vaccines. Regulatory …
arisen in their possible influence on the immune response induced by vaccines. Regulatory …
TGF-β2 interfering oligonucleotides used as adjuvants for microbial vaccines
L Tu, X Sun, L Yang, T Zhang, X Zhang… - Journal of Leucocyte …, 2020 - academic.oup.com
The success of using immune checkpoint inhibitors to treat cancers implies that inhibiting an
immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel …
immunosuppressive cytokine, such as TGF-β2, could be a strategy to develop novel …
Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii
Background: In recent years, there has been great interest in developing molecular
adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor …
adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor …
A LAG3-interfering oligonucleotide acts as an adjuvant to enhance the antibody responses induced by recombinant protein vaccines and inactivated influenza virus …
Z Li, Y Song, C Cui, Y Lan, X Li, Y Liu, F Lu… - Applied microbiology …, 2019 - Springer
Abstract Lymphocyte activation gene-3 (LAG3) is a transmembrane protein expressed on
activated T cells and delivers inhibitory signals to render the T cells unable to effectively help …
activated T cells and delivers inhibitory signals to render the T cells unable to effectively help …
Vaccine-induced effects on regulatory T cell function: autoimmune perspective
A Batista-Duharte - Regulatory T Cells and Autoimmune Diseases, 2024 - Elsevier
Regulatory T cells (Tregs) are essential for maintaining peripheral tolerance, preventing
autoimmune diseases, and limiting chronic inflammatory diseases. Numerous studies have …
autoimmune diseases, and limiting chronic inflammatory diseases. Numerous studies have …