Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Immune dysfunction is caused by various factors, including changes in relevant immune
regulators and environmental stress. Immune system imbalance leads to a variety of …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

Patterns of DNA methylation are established during embryonic development and faithfully
copied through somatic cell divisions. Based on current understanding of DNA methylation …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

Rheumatoid arthritis (RA) is a long-term autoimmune disease of unknown etiology that leads
to progressive joint destruction and ultimately to disability. RA affects as much as 1% of the …