Melatonin and pathological cell interactions: Mitochondrial glucose processing in cancer cells

RJ Reiter, R Sharma, S Rosales-Corral… - International journal of …, 2021 - mdpi.com
Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

Obesity, cancer risk, and time-restricted eating

M Das, NJG Webster - Cancer and Metastasis Reviews, 2022 - Springer
Obesity and the associated metabolic syndrome is considered a pandemic whose
prevalence is steadily increasing in many countries worldwide. It is a complex, dynamic, and …

Effect of miR-34a on the expression of clock and clock-controlled genes in DLD1 and Lovo human cancer cells with different backgrounds with respect to p53 …

R Moravčík, S Olejárová, J Zlacká, I Herichová - Plos one, 2023 - journals.plos.org
The small non-coding RNA miR-34a is a p53-regulated miRNA that acts as a tumour
suppressor of colorectal cancer (CRC). Oncogenesis is also negatively influenced by …

CircCOL5A1 is involved in proliferation, invasion, and inhibition of ferroptosis of colorectal cancer cells via miR‐1287‐5p/SLC7A11

J Wang, Z Zhang, J Zhuang, D Kang… - Journal of Biochemical …, 2024 - Wiley Online Library
Colorectal cancer (CRC) is the leading cause of cancer‐related death globally. Circular
RNA circCOL5A1 plays an oncogene function in a variety of tumors. However, the function of …

Mapping human disease-associated enzymes into Reactome allows characterization of disease groups and their interactions

C Savojardo, D Baldazzi, G Babbi, PL Martelli… - Scientific Reports, 2022 - nature.com
According to databases such as OMIM, Humsavar, Clinvar and Monarch, 1494 human
enzymes are presently associated to 2539 genetic diseases, 75% of which are rare (with an …

[PDF][PDF] The effect and underlying mechanism of sleep deprivation on several gastrointestinal physiology and diseases

YF Li, LY Niu, JF Fan, ZC Yao, LY Shen… - Medicine …, 2024 - scholar.archive.org
The incidence of sleep deprivation has increased significantly in contemporary society.
Gastrointestinal diseases, one of the diseases with high incidence caused by sleep …

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development

B Zhao, E Nepovimova, Q Wu - Cell Communication and Signaling, 2025 - Springer
The complex interaction between circadian rhythms and physiological functions is essential
for maintaining human health. At the heart of this interaction lies the PERIOD proteins …

CpG Site-Based Signature Predicts Survival of Colorectal Cancer

J Wu, L Zhang, A Kuchi, D Otohinoyi, C Hicks - Biomedicines, 2022 - mdpi.com
Background: A critical unmet medical need in clinical management of colorectal cancer
(CRC) pivots around lack of noninvasive and or minimally invasive techniques for early …

Chronobiology and Nanotechnology for Personalized Cancer Therapy

T Albuquerque, AR Neves, R Faria, T Quintela… - Cancer …, 2022 - Springer
As a consequence of Earth's rotation in its axis, most organisms in this planet are subjected
to a 24-hour variation in light and temperature. A diverse range of species developed an …

The role of circadian gene timeless in gastrointestinal cancers

K Hosseini, SM Beirami, H Forouhandeh, SZ Vahed… - Gene Reports, 2023 - Elsevier
Timeless is an evolutionarily preserved protein involved in the circadian rhythm of
melanogaster flies while its role in mammalian circadian clock systems has not been fully …