SOX4: The unappreciated oncogene
CS Moreno - Seminars in cancer biology, 2020 - Elsevier
SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …
differentiation, progenitor development, and multiple developmental pathways including …
U1 snRNP regulates cancer cell migration and invasion in vitro
Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
[HTML][HTML] Expression and putative role of mitochondrial transport proteins in cancer
O Lytovchenko, ERS Kunji - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is
the Warburg effect, in which pyruvate is used for fermentation rather for oxidative …
the Warburg effect, in which pyruvate is used for fermentation rather for oxidative …
[HTML][HTML] Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display
variable sensitivity to therapeutics and may play different roles in progression. We previously …
variable sensitivity to therapeutics and may play different roles in progression. We previously …
[HTML][HTML] Genome-wide analysis of pre-mRNA 3′ end processing reveals a decisive role of human cleavage factor I in the regulation of 3′ UTR length
Through alternative polyadenylation, human mRNAs acquire longer or shorter 3′
untranslated regions, the latter typically associated with higher transcript stability and …
untranslated regions, the latter typically associated with higher transcript stability and …
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
Non-small-cell lung cancer is the leading cause of cancer-related death worldwide.
Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce …
Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide effectively reduce …
A three-gene model to robustly identify breast cancer molecular subtypes
Abstract Background Single sample predictors (SSPs) and Subtype classification models
(SCMs) are gene expression–based classifiers used to identify the four primary molecular …
(SCMs) are gene expression–based classifiers used to identify the four primary molecular …
Claudin-low breast cancers: clinical, pathological, molecular and prognostic characterization
R Sabatier, P Finetti, A Guille, J Adelaide, M Chaffanet… - Molecular cancer, 2014 - Springer
Background The lastly identified claudin-low (CL) subtype of breast cancer (BC) remains
poorly described as compared to the other molecular subtypes. We provide a …
poorly described as compared to the other molecular subtypes. We provide a …
Large-scale RNA-Seq transcriptome analysis of 4043 cancers and 548 normal tissue controls across 12 TCGA cancer types
L Peng, XW Bian, DK Li, C Xu, GM Wang, QY Xia… - Scientific reports, 2015 - nature.com
Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …
Cellular network entropy as the energy potential in Waddington's differentiation landscape
Differentiation is a key cellular process in normal tissue development that is significantly
altered in cancer. Although molecular signatures characterising pluripotency and …
altered in cancer. Although molecular signatures characterising pluripotency and …