Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

The paradigm of cancer-targeted therapies has focused largely on inhibition of critical
pathways in cancer. Conversely, conditional activation of signaling pathways as a new …

Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …