The molecular hallmarks of the serrated pathway in colorectal cancer

FDE De Palma, V D'argenio, J Pol, G Kroemer… - Cancers, 2019 - mdpi.com
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

[HTML][HTML] Colorectal peritoneal metastases: Optimal management review

JM Sánchez-Hidalgo, L Rodríguez-Ortiz… - World journal of …, 2019 - ncbi.nlm.nih.gov
The peritoneum is a common site of dissemination for colorrectal cancer, with a poorer
prognosis than other sites of metastases. In the last two decades, it has been considered as …

Development of a novel combined nomogram model integrating deep learning-pathomics, radiomics and immunoscore to predict postoperative outcome of colorectal …

R Wang, W Dai, J Gong, M Huang, T Hu, H Li… - Journal of hematology & …, 2022 - Springer
Limited previous studies focused on the death and progression risk stratification of colorectal
cancer (CRC) lung metastasis patients. The aim of this study is to construct a nomogram …

Metastatic patterns and survival outcomes in patients with stage IV colon cancer: a population‐based analysis

J Wang, S Li, Y Liu, C Zhang, H Li, B Lai - Cancer medicine, 2020 - Wiley Online Library
Background The goal of this study was to delineate the patterns of distant metastasis from
colon adenocarcinoma (CAC) and evaluate the survival differences by metastatic patterns …

Clinical response to immunotherapy targeting programmed cell death receptor 1/programmed cell death ligand 1 in patients with treatment-resistant microsatellite …

C Wang, J Sandhu, C Ouyang, J Ye, PP Lee… - JAMA network …, 2021 - jamanetwork.com
Importance Microsatellite stable (MSS) metastatic colorectal cancer has been historically
characterized as resistant to immunotherapy. Recent studies have demonstrated limited …

Population-based SEER analysis of survival in colorectal cancer patients with or without resection of lung and liver metastases

AR Siebenhüner, U Güller, R Warschkow - Bmc Cancer, 2020 - Springer
Background Approximately one third of all patients with CRC present with, or subsequently
develop, colorectal liver metastases (CRLM). The objective of this population-based …

Colorectal cancer biology, diagnosis, and therapeutic approaches

B Dariya, S Aliya, N Merchant, A Alam… - Critical Reviews™ in …, 2020 - dl.begellhouse.com
Colorectal cancer (CRC) is the second most diagnosed disease worldwide. It is the fourth
leading cause of cancer related mortalities. Higher probability for the occurrence of CRC is …

Recent updates on the significance of KRAS mutations in colorectal cancer biology

L László, A Kurilla, T Takács, G Kudlik, K Koprivanacz… - Cells, 2021 - mdpi.com
The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming …

Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

J Sun, C Wang, Y Zhang, L Xu, W Fang, Y Zhu… - Nature …, 2019 - nature.com
Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding
of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing …

Reviewing cancer's biology: an eclectic approach

I Diori Karidio, SH Sanlier - Journal of the Egyptian National Cancer …, 2021 - Springer
Background Cancer refers to a group of some of the worldwide most diagnosed and
deadliest pathophysiological conditions that conquered researchers' attention for decades …