Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …

The hypothalamic-pituitary-adrenal axis exerts profound, multilevel inhibitory effects on the
female reproductive system. Corticotropin-releasing hormone (CRH) and CRH-induced …

The human circadian system anticipates and adapts to daily environmental changes to
optimise behaviour according to time of day and temporally partitions incompatible …

ContextInvestigators first described the night-eating syndrome (NES), which consists of
morning anorexia, evening hyperphagia, and insomnia, in 1955, but, to our knowledge, this …

Over the last century there has been a trend toward an earlier onset of menarche attributed
to better nutrition and body fatness. With the discovery of the obesity gene and its product …

Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine
products produced by adipose tissue are tumour necrosis factor α, interleukin 6, acylation …

Recent animal and human studies have suggested that leptin secretion is closely linked to
the functions of the hypothalamic-pituitary-adrenal (HPA) axis and the immune system, both …

The identification and sequencing of the ob gene and its product, leptin, in late 1994 opened
new insights in the study of the mechanisms controlling body weight and led to a surge of …

Objective: The objective of this study was to determine the influence of birth weight and
postnatal weight gain on age at menarche. Design, Setting, and Participants: This was a …

The aim of the current study was to investigate the effects of sleep loss on the diurnal rhythm
of circulating leptin levels. An indwelling forearm catheter was used to sample blood at 90 …