The relationships between stress, mental disorders, and epigenetic regulation of BDNF

Z Miao, Y Wang, Z Sun - International journal of molecular sciences, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF), a critical member of the neurotrophic family, plays
an important role in multiple stress-related mental disorders. Although alterations in BDNF in …

On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective

Z Nouri, S Fakhri, FF El-Senduny, N Sanadgol… - Biomolecules, 2019 - mdpi.com
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …

Naringenin: its chemistry and roles in neuroprotection

AV Atoki, PM Aja, TS Shinkafi, EN Ondari… - Nutritional …, 2024 - Taylor & Francis
According to epidemiological research, as the population ages, neurological illnesses are
becoming a bigger issue. Despite improvements in the treatment of these diseases, there …

[HTML][HTML] Uncoupling proteins as a therapeutic target for the development of new era drugs against neurodegenerative disorder

R Kumar, T Amruthanjali, S Singothu, SB Singh… - Biomedicine & …, 2022 - Elsevier
Mitochondrial uncoupling proteins (UCP) are a part of the large family of mitochondrial
solute carriers (SLC25s), concentrated in the inner mitochondrial membrane that carries …

Involvement of brain‐derived neurotrophic factor methylation in the prefrontal cortex and hippocampus induced by chronic unpredictable mild stress in male mice

S Cheng, W Wang, Z Zhu, M Zhao, H Li… - Journal of …, 2023 - Wiley Online Library
Early life stress alters brain‐derived neurotrophic factor (BDNF) promoter IV methylation and
BDNF expression, which is closely related to the pathophysiological process of depression …

Modifications of behavior and inflammation in mice following transplant with fecal microbiota from children with autism

E Avolio, I Olivito, E Rosina, L Romano, T Angelone… - Neuroscience, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder displaying the
modification of complex human behaviors, characterized by social interaction impairments …

The responsive mechanisms of DNA methylation and transcriptional regulation to acute hypoxia stress in HIF-1/VEGFA signal pathway of Japanese flounder …

B Liu, G Li, X Li, H Wang, J Yang, H Wen, F He - Aquaculture, 2024 - Elsevier
The area of marine hypoxia is gradually expanding. This phenomenon seriously affects the
normal life activities of a variety of marine organisms. Japanese flounder (Paralichthys …

Behavior, BDNF and epigenetic mechanisms in response to social isolation and social support in middle aged rats exposed to chronic stress

JV Borges, VN Pires, BS de Freitas… - Behavioural brain …, 2023 - Elsevier
Social deprivation can be stressful for group-living mammals. On the other hand, an
amazing response of these animals to stress is seeking social contact to give and receive …

Redox modification of ryanodine receptor contributes to impaired Ca2+ homeostasis and exacerbates muscle atrophy under high altitude

A Agrawal, R Rathor, R Kumar, G Suryakumar… - Free Radical Biology …, 2020 - Elsevier
At extreme altitude, prolonged and severe hypoxia menaces human function and survival,
and also associated with profound loss of muscle mass which results into a debilitating …

Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory

Q Kong, M Yu, M Zhang, C Wei, H Gu, S Yu, W Sun… - Molecular Brain, 2020 - Springer
Aim Active changes in neuronal DNA methylation and demethylation appear to act as
controllers of synaptic scaling and glutamate receptor trafficking in learning and memory …