Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in
addition to its classical role in pH regulation, it has also been proposed to participate in cell …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of enzymes widespread in all
life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types …

Cells of the growing tumor tissue are exposed to physiological stresses connected with
insufficient delivery of oxygen (hypoxia) and accumulation of acidic products of the glycolytic …

Among the 16 different α-carbonic anhydrase (CA, EC 4.2. 1.1) isoforms isolated in
mammals, 13 possess catalytic activity for the reversible hydration of carbon dioxide to …

Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to
inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at …

The carbonic anhydrase (CA, EC 4.2. 1.1) isozymes IX and XII are predominantly found in
tumor cells and show a restricted expression in normal tissues. By efficiently hydrating …

The chemistry of 1, 3, 4-thiadiazoles is very well known. A universal and commonly used
method of the synthesis of different 2, 5-disubstituted 1, 3, 4-thiadiazoles includes the …