Recurrence in glioblastoma is nearly universal, and its prognosis remains dismal despite
significant advances in treatment over the past decade. Glioblastoma demonstrates …

Despite the multidisciplinary integration in the therapeutic management of glioblastoma
multiforme (GBM), the prognosis of GBM patients is poor. There is growing recognition that …

Purpose: Despite the use of fluorescence-guided surgery (FGS), maximum safe resection of
glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons …

Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct
conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal …

Background Surgical resection is a universal component of glioma therapy. Little is known
about the postoperative microenvironment due to limited preclinical models. Thus, we …

To maximize tumor excision and minimize collateral damage are the primary goals of cancer
surgery. Emerging molecular imaging techniques have made “image-guided surgery” …

Glioblastoma multiforme (GBM) is the most common and devastating type of primary brain
cancer. Despite surgery and chemo/radiation therapy, recurrence often takes place and …

Despite the proven safety of oncolytic viruses (OV) in clinical trials for glioblastoma (GBM),
their efficacy has been hindered by suboptimal spreading within the tumor. We show that …

Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma
(GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous …

A major malignant trait of gliomas is their remarkable infiltration capacity. When glioma
develops, the tumor cells have already reached the distant part. Therefore, complete …