Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

To effect movement, motoneurons must respond appropriately to motor commands. Their
responsiveness to these inputs, or excitability, is regulated by neuromodulators. Possible …

We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-
amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester (retigabine), in rat models …

Spike frequency adaptation (SFA) is a fundamental property of repetitive firing in
motoneurones (MNs). Early SFA (occurring over several hundred milliseconds) is thought to …

Spike-frequency adaptation causes reduced spiking during prolonged stimulation, but the
full impact of adaptation on neural coding is far more complex, especially if one takes into …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still
missing effective therapeutic strategies. Although manipulation of neuronal excitability has …

Delayed rectifier K+ currents are involved in the control of α‐motoneurone excitability, but
the precise spatial distribution and organization of the membrane ion channels that …

To investigate the effect of initial conditions on the modulation of motor unit discharge during
fast voluntary contractions, we compared ballistic isometric contractions of the ankle …

Voltage-sensitive ionic currents shape both the firing properties of neurons and their
synaptic integration within neural networks that drive rhythmic motor patterns. Persistent …