Thorough research on HIV is progressively enabling us to understand the intricate
mechanisms that link HIV‐1 infection to the onset of immunodeficiency. The infection and …

Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases.
They probably act, in most cases, by blunting the infection, which is then resolved by cellular …

During immune responses, T cells are subject to clonal competition, which leads to the
predominant expansion of high-affinity clones; however, there is little understanding of how …

Cytotoxic CD8 T cells are key effectors in the immunotherapy of malignant and viral
diseases. However, the lack of efficient methods for their in vitro priming and expansion has …

Dengue virus presents a growing threat to public health in the developing world. Four major
serotypes of dengue virus have been characterized, and epidemiological evidence shows …

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV)
infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in …

T cells expressing antigen-specific T-cell receptors (TCRs) can mediate effective tumor
regression, but they often also are accompanied by autoimmune responses. To determine …

Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T
cell receptor (TCR) affinity to the relevant pathogen-associated antigens. However, low …

To generate chimeric Ag receptors (CARs) for the adoptive immunotherapy of cancer
patients with ErbB2-expressing tumors, a single-chain Ab derived from the humanized mAb …

Because of the large preexisting antigenic load and immunosuppressive environment within
a tumor, inducing therapeutically useful antitumor immunity in cancer patients requires the …