Developing sensory circuits exhibit different patterns of spontaneous activity, patterns that
are related to the construction and refinement of functional networks. During the …

During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion
molecules with emerging functions in cortical development and synapse formation. Their …

FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell
adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How …

Highlights•Thalamocortical interactions are crucial for thalamic and cortical
development.•Cortical neuronal specification and areas size are influenced by the …

The development of Gonadotropin releasing hormone-1 (GnRH) neurons is important for a
functional reproduction system in vertebrates. Disruption of GnRH results in hypogonadism …

Precise wiring of neural circuits is essential for brain connectivity and function. During
development, axons respond to diverse cues present in the extracellular matrix or at the …