Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
Tracking chromatin state changes using nanoscale photo-proximity labelling
Interactions between biomolecules underlie all cellular processes and ultimately control cell
fate. Perturbation of native interactions through mutation, changes in expression levels or …
fate. Perturbation of native interactions through mutation, changes in expression levels or …
Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler
NJ Abdulhay, LJ Hsieh, CP McNally… - Nature Structural & …, 2023 - nature.com
Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …
However, our understanding of how these processes (for example, DNA replication, RNA …
Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
[HTML][HTML] Human SMARCA5 is continuously required to maintain nucleosome spacing
Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …
Transcription-coupled nucleosome assembly
F Robert, C Jeronimo - Trends in Biochemical Sciences, 2023 - cell.com
Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …
Physical nature of chromatin in the nucleus
K Maeshima, S Iida, S Tamura - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
Genomic information is encoded on long strands of DNA, which are folded into chromatin
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …
Massively multiplex single-molecule oligonucleosome footprinting
NJ Abdulhay, CP McNally, LJ Hsieh, S Kasinathan… - Elife, 2020 - elifesciences.org
Our understanding of the beads-on-a-string arrangement of nucleosomes has been built
largely on high-resolution sequence-agnostic imaging methods and sequence-resolved …
largely on high-resolution sequence-agnostic imaging methods and sequence-resolved …
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing
E Oberbeckmann, V Niebauer, S Watanabe… - Nature …, 2021 - nature.com
Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by
alignment to reference sites like active promoters. How the distances between nucleosomes …
alignment to reference sites like active promoters. How the distances between nucleosomes …