Evolving concepts on bradykinesia

M Bologna, G Paparella, A Fasano, M Hallett… - Brain, 2020 - academic.oup.com
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond

W Bouthour, P Mégevand, J Donoghue… - Nature Reviews …, 2019 - nature.com
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication

G Tinkhauser, A Pogosyan, H Tan, DM Herz, AA Kühn… - Brain, 2017 - academic.oup.com
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with
Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of …

Device profile of the percept PC deep brain stimulation system for the treatment of Parkinson's disease and related disorders

J Jimenez-Shahed - Expert Review of Medical Devices, 2021 - Taylor & Francis
Introduction: Several software and hardware advances in the field of deep brain stimulation
(DBS) have been realized in recent years and devices from three manufacturers are …

Neurostimulation devices for the treatment of neurologic disorders

CA Edwards, A Kouzani, KH Lee, EK Ross - Mayo Clinic Proceedings, 2017 - Elsevier
Rapid advancements in neurostimulation technologies are providing relief to an
unprecedented number of patients affected by debilitating neurologic and psychiatric …

[HTML][HTML] Local field potentials in Parkinson's disease: a frequency-based review

Z Yin, G Zhu, B Zhao, Y Bai, Y Jiang… - Neurobiology of …, 2021 - Elsevier
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field
potentials (LFPs), the electrophysiological population activity of neurons surrounding the …

Debugging adaptive deep brain stimulation for Parkinson's disease

S Little, P Brown - Movement Disorders, 2020 - Wiley Online Library
Deep brain stimulation (DBS) is a successful treatment for patients with Parkinson's disease.
In adaptive DBS, stimulation is titrated according to feedback about clinical state and …

[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

R Lofredi, L Okudzhava, F Irmen, C Brücke… - npj Parkinson's …, 2023 - nature.com
Pathologically increased beta power has been described as a biomarker for Parkinson's
disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we …

Evidence of neuroplastic changes after transcranial magnetic, electric, and deep brain stimulation

J Kricheldorff, K Göke, M Kiebs, FH Kasten… - Brain Sciences, 2022 - mdpi.com
Electric and magnetic stimulation of the human brain can be used to excite or inhibit
neurons. Numerous methods have been designed over the years for this purpose with …