Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

This critical review provides an overview of the continually expanding family of fluorescent
proteins (FPs) that have become essential tools for studies of cell biology and physiology …

The whole picture: Carbon nanodots labeled with two fluorescent dyes have been
developed as a tunable ratiometric pH sensor to measure intracellular pH. The nanosensor …

Superresolution imaging is a rapidly emerging new field of microscopy that dramatically
improves the spatial resolution of light microscopy by over an order of magnitude (∼ 10–20 …

Fluorescence has long been recognized as a powerful tool for probing biological structure
and function. Nearly sixty-five years ago, Coons and colleagues introduced the first …

Fluorescent proteins have revolutionized cell biology by allowing researchers to non-
invasively peer into the inner workings of cells and organisms. While the most common …

Regeneration requires exquisite orchestration of growth and morphogenesis. A powerful but
still largely mysterious system of biophysical signals functions during regeneration …

We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and
biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4 …

Polarity-dependent fluorescent probes are recently attracting interest for high-resolution cell
imaging. Following a stepwise rational approach, we prepared and tested a toolbox of new …

Intracellular chloride ([Cl−] i) and pH (pHi) are fundamental regulators of neuronal
excitability. They exert wide-ranging effects on synaptic signaling and plasticity and on …